This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens.
This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens. These parameters will be assessed in patients currently receiving high-bicarbonate hemodialysis as part of usual care. They will then be switched to a lower bicarbonate prescription, after which these parameters will be reassessed. The study will also examine changes in inflammatory markers, glycemic control, ketogenesis, and lipolysis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
7
Low bicarbonate hemodialysis - 30 mEq/L dialysate bicarbonate
Albert Einstein College of Medicine
The Bronx, New York, United States
Pre-dialysis serum bicarbonate
Change in predialysis bicarbonate
Time frame: 5 weeks
serum beta-hydroxybutyrate
Change in beta-hydroxybutyrate during dialysis
Time frame: 5 weeks
beta-hydroxybutyrate clearance
Change in clearance between different dialysates
Time frame: 5 weeks
interleukin-6
Change during dialysis
Time frame: 5 weeks
serum free fatty acids
Change during dialysis
Time frame: 5 weeks
Time to recover from dialysis
Change between dialysates
Time frame: 5 weeks
Dialysis symptom questionnaire
Change between dialysates
Time frame: 5 weeks
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