Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol

Inclusion Criteria: * Patients \>/= 30 and \</= 85 years of age * Male or female with aortic valve disease * Able to understand character and individual consequences of the clinical trial and to provide written informed consent to participate in the study * Women of childbearing potential (ie, those who have not undergone a hysterectomy or who have not been post-menopausal for at least 12 consecutive months) must test negative for pregnancy prior to bypass surgery. Exclusion Criteria: * History of recent (\< 6 weeks) Q-wave myocardial infarction * Left ventricular ejection fraction \< 25% (as assessed by any one of the following: contrast ventriculography, multigated acquisition scanning \[MUGA\], or 2-D ECHO) * Patients on intra-aortic balloon devices or with history of previous coronary artery bypass surgery * Pregnant or lactating patients * Patients who have participated in any other investigational studies within 30 days previous to enrollment * Patients in cardiogenic shock (defined as a systolic BP \< 90 mmHg for over one hour despite inotropic and chronotropic support) * Patients with severe chronic obstructive lung disease (FEV1 \< 50%) * Previous cardiac valvular disease (clinical relevant) * GFR \<60 ml/min * Planned Ross-procedure, Mitral valve surgery, Aortic valve reconstruction, double valve surgery, other concomitant operations excluding coronary artery bypass surgery or closing a patent foramen ovale * Evidence of severe organic (e.g. cirrhosis of the liver) or psychiatric disease by history or physical examination * History of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or any history of drug abuse or addiction within 12 months of study enrollment.