Effects of Coffee Consumption on Glucose Metabolism

N/ACompletedNCT02099929

University of Brasilia14 enrolled

Overview

Epidemiological studies have shown an inverse association between coffee consumption and risk of type 2 diabetes mellitus (T2DM). However the experimental studies that analysed the mechanisms are limited. This project aims to assess the effects of coffee consumption on glucose metabolism, using stable isotope tracer (13C-glucose) to explain the possible metabolic mechanisms involved on the reduced risk for T2DM.

This is a crossover randomized clinical trial that has been studying 14 male healthy young adults, who were enrolled five treatments: coffee with sugar, coffee without sugar, decaffeinated coffee without sugar and two controls (water with and without sugar). The stable isotope minimal model protocol with oral glucose administration (Oral Dose Intravenous Label Experiment - ODILE) was performed. The use of ODILE methodology permits separation of the glucose absorbed and removed from the circulation increasing the accuracy and the effectiveness of glucose uptake and insulin sensitivity (Bluck et al., 2006).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

Coffee with SugarOTHER

300mL of Coffee with 30g of Sugar

Coffee without SugarOTHER

300mL of Coffee without Sugar

Decaffeinated Coffee without SugarOTHER

300mL of Decaffeinated Coffee without Sugar

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male healthy young adults (18 - 50 years old); * Body mass index (BMI) between 18.5 - 28.0 kg/m²; * No weight changes (≥ 5 kg) in the last 3 months; * Not take any pills/drugs that alter metabolism, appetite and sleep; * Not have sleep disorders; * Not have donated blood in the last 3 months; * Regular breakfast consumption (≥100 kcal ingested up to 2 hours after waking ≥4x/week); * Being a habitual coffee consumer (≥100mL ≥5x/week). Exclusion Criteria: * Diagnosis of anemia, metabolic and heart diseases; * Previous sudden fainting and convulsions; * Any drugs and tobacco consumption; * Consumption of more than 500mg of caffeine / day (5 cups of coffee, tea and cola soft drinks).

Locations (1)

Laboratório de Bioquímica da Nutrição, Núcleo de Nutrição e Medicina Tropical, Universidade de Brasília

Brasília, Federal District, Brazil

Outcomes

Primary Outcomes

ODILE minimal model analysis

The stable isotope minimal model protocol with oral glucose administration (Oral Dose Intravenous Label Experiment - ODILE)

Time frame: -10, 0, 30, 60/0, 15, 30, 45, 47, 49, 51, 53, 55, 57, 59, 61, 65, 70, 75, 80, 85, 90, 100, 115, 135, 165, 195, 225 minutes.

Secondary Outcomes

Glucose metabolism

Glucose and Insulin levels, and Insulin sensitivity indices.

Time frame: -10, 0, 30, 60/0, 15, 30, 45, 47, 49, 51, 53, 55, 57, 59, 61, 65, 70, 75, 80, 85, 90, 100, 115, 135, 165, 195, 225 minutes.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.