Safety & Immunogenicity of HIV Vaccines in Healthy Kenyan Adults

Inclusion Criteria: * Healthy adults aged 18-50 * Willing to comply with the requirements of the protocol and available for follow-up for the planned duration of the study. * Written informed consent. * Willing to undergo HIV-1 testing, counselling and receive test results. * All female volunteers must be willing to undergo urine pregnancy tests * If sexually active using an effective method of contraception until at least 4 months after the last vaccination. * Willing to forgo donating blood during the study. Exclusion Criteria: * Any relevant abnormality on history or examination including history of immunodeficiency or autoimmune disease, or use of systemic corticosteroids, immunosuppressive, antiviral, anticancer or other medication that, in the opinion of the Principal Investigator or designee, is clinically significant, within the previous 6 months. (Note: use of inhaled steroids for asthma or use of topical steroids for localized skin conditions will not exclude a volunteer from participation.) * Any clinically significant acute or chronic medical condition that is considered progressive or, in the opinion of the Principal Investigator or designee, would make the volunteer unsuitable for the study. * Any of the following abnormal laboratory parameters (1 abnormal test may be repeated once if thought to be due to a temporary condition): * Haematology * Haemoglobin \< 9.0 g/dl for women and \<11.0 g/dl for men * Absolute Neutrophil Count (ANC) ≤ 1000 /mm3 (≤ 1 x 109 /l) * Absolute Lymphocyte Count (ALC) ≤ 600 /mm3 (≤0.6 x 109 /l) * Platelets ≤100,000 /mm3, ≥ 550,000 /mm3 (≤ 100 /l, ≥ 550 /l) * Biochemistry * Creatinine \> 1.3 x upper limit of normal (ULN) * Aspartate aminotransferase (AST) \> 2.5 x ULN * Alanine aminotransferase (ALT) \> 2.5 x ULN * Urinalysis- Clinically significant abnormal dipstick confirmed by microscopy: * Protein = 2+ or more * Blood = 2+ or more (for women: before or after menses) * Confirmed HIV-1 or HIV-2 infection. * If female, pregnant or planning a pregnancy any time from enrolment to 4 months after the last vaccination; or lactating. * Receipt of live attenuated vaccine within the previous 60 days or planned receipt at any time until 60 days after vaccination with Investigational Medicinal Product (IMP) or receipt of other vaccine, including influenza vaccine, within the previous 14 days or planned receipt at any time until 14 days after vaccination with the IMP. * Receipt of blood transfusion or blood products within the previous 6 months. * Participation in another clinical trial of an IMP currently or within the previous 3 months or expected participation during this study. * Receipt of any investigational HIV-1 vaccine within the last 6 years. * History of severe or very severe local or systemic reactogenicity events after vaccination, or history of severe or very severe allergic reactions. * Confirmed diagnosis of acute or chronic hepatitis B virus infection (spontaneous clearance leading to natural immunity, indicated by antibodies to core + antigens, is not an exclusion criterion); confirmed diagnosis of hepatitis C virus infection; untreated syphilis. * Smallpox vaccination within the previous 3 years. * Major psychiatric illness in the previous 3 years. * History of allergy or hypersensitivity to latex, chronic skin problems such as eczema or psoriasis, or skin and subcutaneous tissue thickness \> 40 mm as assessed by skin pinch test in either deltoid region. * Presence of an implantable device * Current use of any electronic stimulation device. Therapeutic or traumatic metal implant in either deltoid region. * History of, or known active cardiac disease or a heart condition under the care of a doctor. Note: Slight physiological variation of normal resting heart rate (60 - 100 beats/minute) with respiration is NOT excluded. * History of syncope or fainting episode within 1 year of study entry. * Seizure disorder or any history of prior seizure.