Esophageal Cytology With FISH in Detecting Esophageal Cancer

Inclusion Criteria: * Subjects with known esophageal cancer diagnosed by previous endoscopy * Adenocarcinoma * Squamous cell carcinoma * Patients determined to be at risk for esophageal cancer: * Subjects with a history of Barrett's esophagus * Subjects with a history of low or high grade dysplasia * Subjects with a history of gastroesophageal reflux disease (GERD) * Subjects with a history of esophagitis * Subjects with symptoms of esophageal cancer (EC) referred for endoscopy (new onset dysphagia, weight loss, etc) * Patients must be scheduled for a procedure capable of providing a definitive pathological diagnosis and evaluating for complications of the esophageal sponge on the same day as the study procedure, either: * Upper endoscopy * Surgical esophagectomy * Subjects with Eastern Cooperative Oncology Group (ECOG) performance status =\< 3 (Karnofsky \>= 30%) will be included * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Subjects with severe, symptomatic dysphagia (unable to pass solids) * Subjects that are unable to swallow a tablet/pill for any reason * Subjects with a previous esophagectomy * Subjects with esophageal varices * Subjects unable to provide consent * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements