Chlorthalidone and HCTZ Impacts on Platelet Activation

Inclusion Criteria: * Men or women age 19 or older * Not currently taking any routinely scheduled prescription or over the counter medications or herbal supplements * No use of aspirin, clopidogrel, prasugrel, ticagrelor, cilostazol, dipyridamole, NSAID medications, or herbal supplements within the previous 7 days and able to refrain from use during the study period * Systolic blood pressure \> 110 mmHg and diastolic blood pressure \> 60 mmHg * Non-smoker Exclusion Criteria: * Previous adverse reaction or allergy to HCTZ, CTD, or ASA * Severe sulfonamide hypersensitivity (anaphylaxis or Stevens-Johnson syndrome) * Diagnosis of any chronic disease or condition * History of gout or hyperuricemia * History of pancreatitis * History of systemic lupus erythematosus (SLE) * History of hypokalemia requiring treatment * Pregnant or planning to become pregnant during the study period * Breastfeeding * History of hypotension * History of gastrointestinal bleeding