The purpose of this study is to evaluate the effect of concomitant administration of BMS-986020 on the single dose Pharmacokinetics (PK) of Rosuvastatin in healthy subjects.
Study Type
INTERVENTIONAL
Masking
NONE
Enrollment
26
Healthcare Discoveries, Llc D/B/A Icon Development Solutions
San Antonio, Texas, United States
Maximum observed plasma concentration (Cmax) of Rosuvastatin with and without coadministered BMS-986020
Time frame: 31 timepoints up to Day 12
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration (AUC(0-T)) of Rosuvastatin with and without coadministered BMS-986020
Time frame: 31 timepoints up to Day 12
Area under the plasma concentration-time curve from time zero extrapolated to infinite time (AUC(INF)) of Rosuvastatin with and without coadministered BMS-986020
Time frame: 31 timepoints up to Day 12
Time of maximum observed plasma concentration (Tmax) of Rosuvastatin with and without coadministered BMS-986020
Time frame: 31 timepoints up to Day 12
Terminal plasma half-life (T-HALF) of Rosuvastatin with and without coadministered BMS-986020
Time frame: 31 timepoints up to Day 12
Apparent total body clearance (CLT/F) of Rosuvastatin with and without coadministered BMS-986020
Time frame: 31 timepoints up to Day 12
Incidence of Adverse Event (AEs), Serious Adverse Event (SAEs), deaths, and AEs leading to discontinuation
Time frame: Upto Day 12
Results of vital signs, ECGs, Physical Examination (PEs), and clinical lab result
Time frame: Up to Day 12
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