The Role of Complement Factor H Polymorphism in the Regulation of Choroidal Vascular Tone in Young Healthy Subjects

Inclusion Criteria: * Men and women aged between 18 and 45 years, nonsmokers * Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant * Systolic blood pressure \< 160 mmHg, diastolic blood pressure \< 90 mmHg * Normal ophthalmic findings, ametropia less than 3 diopters Exclusion Criteria: * Regular use of medication * Abuse of alcoholic beverages * Participation in a clinical trial in the 3 weeks preceding the study * Treatment in the previous 3 weeks with any drug (except hormonal contraceptives) * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Blood donation during the previous 3 weeks * History or family history of epilepsy * Pregnancy, planned pregnancy or lactating