Observational Study of Biomarker During Liver Surgery

University of Florida41 enrolled

Overview

The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.

If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Cancer Hepatobiliary Tract Adenomas and Carcinomas

Interventions

Hepatocellular carcinomaPROCEDURE

Participants undergoing a liver resection/liver transplantation surgery. During the liver surgery a small piece of tissue will be removed to undergo additional laboratory testing.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * liver resection \> 2 segments, * plate count \> 100 x 109/L, and * prothrombin activity \>60%. Exclusion Criteria: * liver cirrhosis, * portal hypertension, * steatohepatitis or severe steatosis, * patients receiving additional ablation therapies, * laparoscopic resection, and * simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy

Locations (1)

UF Health

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Biochemical analysis of sirtuin1 from liver tissues during liver surgery

Time frame: 30 minutes during liver surgery

Data from ClinicalTrials.gov

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