Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia

Chang Gung University29 enrolled

Overview

Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Spinocerebellar Ataxia

Interventions

Neuromuscular electrical stimulationDEVICE

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of Spinocerebellar ataxia * No history of epilepsy * No other neuromuscular disorder * No fracture within the last six months and restricted movement on the upper extremity * Limited trembling hand allowed for the EMG recording.

Outcomes

Primary Outcomes

Central Motor Excitability

Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation.

Time frame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.

Peripheral Motor Excitability

Measure of changes in peripheral motor excitability by Maximum M wave and H reflex