The purpose of this study is to compare the quality and duration of pain relief after a hemorrhoidectomy, provided by locally administered liposomal bupivacaine versus bupivacaine hcl or control with saline. It is hypothesized that liposomal bupivacaine will provide more effective postoperative pain relief than both bupivacaine hcl and the control.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
11
266 mg/20mL Exparel (to be diluted with 10 mL sterile saline to make 30 mL)
75mg/30mL 0.25% Bupivacaine HCl with epinephrine
30mL Normal Saline
St.Luke's-Roosevelt Hospital Center
New York, New York, United States
Post Operative Pain Control
The primary objective is to evaluate analgesia following local infiltration of 30 mL Exparel or the same volume of 0.25% bupivacaine HCl with epinephrine or normal saline. The intensity of pain will be measured using a numerical rating scale (NRS-11) in which 0 represents no pain, and 10 represents extreme pain.
Time frame: up to 4 days
Number of Oxycodone Tablets Taken
Number of postoperative opioid consumption - oxycodone tablets (5mg each)
Time frame: up to 4 days
Postoperative Opioid Consumption - Hydromorphone I.V
Time frame: 1 hour and 2 hours post op
Number of Participants With Postoperative Nausea and Vomiting
Number of participants with postoperative nausea and vomiting episodes
Time frame: up to 4 days
Number of Participants With Pain During Bowel Movements
Number of participants with pain during postoperative bowel movements
Time frame: Hourly from PACU arrival to discharge and Q4H from 10:00-22:00 postoperatively for 4 days
Number of Participants With Urinary Retention
Time frame: up to 4 days
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