Stem Cell Therapy to Improve Burn Wound Healing

\- Donors: Eligibility Criteria: * No history of malignancy * No active coagulopathy and/or hypocoagulable state * No history of cardio/pulmonary conditions * Negative tests for Hepatitis A, Hepatitis B, Hepatitis C, RPR, HIV 1 / 2, HTLV I/II, Chagas Disease, NAT for HCV, HIV and WNV. * Hemoglobin ≥ 13.0 g/dL * Platelet count 140,000 to 440,000/ul * WBC 3.0 to 11.0 K/ul * BNP ≤ 100 pg /mL * No anomalies on the CBC and differential suggestive of a hematopoietic disorder * Creatinine ≤ 1.5 mg/dL * ALT ≤ 112 IU/L * AST ≤ 100 IU/L * Bilirubin \< 1.5 mg/dL * No diabetes * Systolic blood pressure ≤ 170 * Diastolic blood pressure ≤ 90 * No history of autoimmune disorders Recipients: Inclusion Criteria: 1. Male or female subjects 18 years of age or older with Superficial, Intermediate or Deep 2nd Degree Burn Wounds 2. Injury within the prior 7 days 3. Subjects must understand and give written informed consent. 4. Subjects must agree to have biopsies performed as per protocol 5. Subjects must be accessible for weekly wound treatment and assessment visits 6. Males and females must agree to use an acceptable method of contraception. Exceptions will be females of non-childbearing age and monogamous males who are partners of females of non-childbearing age. Acceptable methods of birth control include; history of sterilization, birth control pills, depoprogesterone injections, a barrier contraceptive such as a condom with or without spermicide cream or gel, diaphragms or cervical cap with or without spermicide cream or gel, or an intrauterine device (IUD). 7. Maximum wound size limited to: * Single wound: ≤ 5% body surface area (BSA) * Multiple wounds treated in a defined anatomical region with ≤ 20% cumulative BSA. 8. Diabetic subjects: HbA1c ≤ 8% Exclusion Criteria: 1. Solely 1st degree or solely 3rd degree burns 2. Subjects with superficial 2nd degree burn who are expected to heal within 2 weeks post standard therapy 3. Evidence of active infection at the wound site 4. Evidence of significant wound healing prior to treatment 5. Wound located in the area of fingers, toes, face, or perineum 6. Wound where 75% or more extends across joints 7. Electrical or chemical burns 8. Have any requirement for the use of systemic steroids or immunosuppressive 9. Subjects Allergic to human albumin, streptomycin, or penicillin 10. Be a pregnant female or nursing mother 11. Subjects who are known or found to be HIV positive 12. Current history of alcohol or substance abuse or history of alcohol or substance abuse requiring treatment within the past 12 months 13. Patients with severe medical conditions 1. Malignancy (other than non melanoma skin cancer) not in remission or in remission less than 5 years 2. Life expectancy less than two years 3. Severe cardiopulmonary disease restricting ambulation to the clinical facility 14. WBC \<3 or \> 10 x10⁹/L, Hgb \< 9g/dL, platelets count 100x10⁹/L or less, serum creatinine \> 1.5 times the upper normal limit, AST or ALT \> 2.5 times the upper normal limit. 15. Subjects with abnormal bilirubin levels. 16. Subjects with abnormal PT/INR laboratory values while not on chronic anticoagulant treatment which can be held for minor surgical procedures 17. Those with a known history of coagulopathy 18. Subjects who are potential recipients of tissue or organ transplantation 19. Subjects with circulating Hepatitis B antigen and/or who are seropositive for Hepatitis C antibody 20. History of poor compliance, unreliability