Evaluation of the Role of Plasma Procalcitonin in Prediction of Intra-amniotic Infection in Preterm Premature Rupture of Membrane

Ain Shams Maternity Hospital100 enrolled

Overview

It is hypothesized that the procalcitonin has a role to play in prediction of intra-amniotic subclinical infection.

Study population * This study will be conducted at the department of Obstetrics and Gynecology recruiting pregnant women selected from the attendees of antenatal clinic, emergency department and from inpatient wards of Ain Shams University Maternity Hospital from Mars2014. * This study will include 100 pregnant women these cases will be divided into 2 groups: * Group 1: Healthy preterm Group: will include 50 pregnant females all at 24-34 weeks of gestational age . * Group 2: Preterm premature rupture of membrane Group: will include 50 pregnant females all at 24-34 weeks of gestational age

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Intra-amniotic Subclinical Infection.

Interventions

procalcitoninDRUG

In patient with preterm premature rupture of membrane (PPROM) is the procalcitonin can be used to predict intra-amniotic subclinical infection?

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Patients are with singleton pregnancies. Rupture of membranes will be diagnosed by history, sterile speculum examination to confirm fluid leakage from the cervical canal and ultrasound to confirm oligohydraminos. Subclinical infection will be detected with laboratory indices (WBC count of ≥15, 000 c/mm3, CRP of ≥1 mg/dL) without any clinical symptoms and signs of infection as urinary tract infection in group 1 patients. Women with multiple pregnancies. Clinical signs of infection as (fever,abdominal tendernes). Cervical dilatations of 2 cm or more. Maternal disease like diabetes or fetal complications like intra-uterine fetal death. Inclusion Criteria: \- Exclusion Criteria: \-

Locations (1)

Ain Shams Maternity Hospital

Cairo, Egypt

Outcomes

Primary Outcomes

The correlation between procalcitonin level in PPROM and C-reactive protein level in neonates.

The correlation between procalcitonin level in PPROM and C-reactive protein level in neonates

Time frame: one year

Secondary Outcomes

Procalcitonin. - C-reactive protein. - White blood cells count (total and diffrantiated). -C-reactive protein in neonates of groub 2.

Procalcitonin. * C-reactive protein. * White blood cells count (total and diffrantiated). * C-reactive protein in neonates of groub 2.

Time frame: one year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.