This study aims to evaluate skin aging of an homogeneous population of 77 years old patient selected among the PROOF cohort who has been continuously investigated by cardiological examination. Skin aging will be explored by macroscopic and microscopic evaluation. In particular, skin aging will be measured by an index of clinical aging (SCINEXA) and other complementary measures such as facial photos, standard and High Definition dermoscopy, elastography, sebumetry, in vivo and ex vivo confocal microscopy, and classical histological examinations.
Study Type
OBSERVATIONAL
Enrollment
209
Clinical pictures, Dermatoscopy, Elastography, Sebumetry
Skin biopsy for examinations by confocal microscopy ex vivo and histopathology
Examination by confocal microscopy in vivo
CHU de Saint-Etienne
Saint-Etienne, France
SCINEXA score
The aging of the skin is evaluated by a semi-quantitative composite of 19 clinical variables : the score SCINEXA
Time frame: Day 1
in vivo confocal microscopy
Skin aging evaluated by in vivo confocal microscopy
Time frame: Day 1
ex vivo confocal microscopy
Skin aging evaluated by ex vivo confocal microscopy ( thickness of the epidermis with and without the stratum corneum, dermis thickness , number of sweat glands per unit volume).
Time frame: Day 1
histology
Skin aging evaluated by conventional histology (thickness of the epidermis and dermis, presence and degree of elastosis , flattening of the dermo- epidermal junction)
Time frame: Day 1
RAMAN
The composition of subcutaneous fat measured by ex vivo RAMAN spectroscopy
Time frame: Day 1
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