Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Treatment for Resistant Obsessive-compulsive Symptoms in Patients With Schizophrenia

Hospital de Clinicas de Porto Alegre12 enrolled

Overview

This is a study to evaluate the efficacy of rTMS for relief of obsessive-compulsive symptoms in patients with schizophrenia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Schizophrenia Obsessive-Compulsive Symptoms

Interventions

Active rTMSDEVICE

rTMS over supplementary motor area, 1hz, no pauses, 20 minutes/sessions, 5 sessions/week, 4 weeks. Total 20 sessions.

SHAM rTMSDEVICE

Sham rTMS, without brain stimulation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Schizophrenia (DSM-IV-TR) * YBOCS ≥ 16 Exclusion Criteria: * Mental Retardation * Substance abuse * Any contraindication to rTMS

Locations (1)

Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Outcomes

Primary Outcomes

Change of Obsessive Compulsive symptoms (using Yale-Brown Obsessive Compulsive Scale - Y-BOCS)

Time frame: Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment

Secondary Outcomes

Change of Psychotic Symptoms (using Brief Psychiatric Rating Scale - BPRS)

Time frame: Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment

Change of Brain-Derived Neurotrophic Factor (BDNF)

Time frame: Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment

Data from ClinicalTrials.gov

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