The purpose of this study is to compare standard therapy (risk factor control, life style modification) versus standard therapy plus low-dose rosuvastatin therapy (5mg/day) on progression of coronary atherosclerosis in statin naive individuals who have mild CAD (nonobstructive coronary atherosclerotic plaques) and normal LDL (low-density lipoprotein) cholesterol levels(\<130mg/dl).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
111
Risk factor control Diet Exercise for 24months
Risk factor control rosuvastatin 5mg/day for 24months
Asan Medical Center
Seoul, South Korea
Percent change in total atheroma volume(TAV)
Percent change in total atheroma volume(TAV) at region of interest defined as(TAV at 24 months-TAV at baseline)/(TAV at baseline)x 100
Time frame: 2 years
Change in PAV(Percent atheroma volume) at region of interest
Change in PAV(Percent atheroma volume) at region of interest(PAV at 24months-PAV at baseline)
Time frame: 2years
Change in overall TAV
Sum of TAV in all coronary segments
Time frame: 2years
Change in TAV at region of interest
TAV at 24months-TAV at baseline
Time frame: 2years
Change in overall CAC(coronary artery calcification) score
overall CAC score at 24months-overall CAC score at baseline
Time frame: 2years
Change in number of segment of any coronary atherosclerotic plaques
Time frame: 2years
Percent change from baseline in lipid levels
Time frame: 2years
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