Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors

Memorial Sloan Kettering Cancer Center133 enrolled

Overview

This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.

Study Type

OBSERVATIONAL

Enrollment

133

Conditions

Hodgkin Lymphoma Survivor

Interventions

Clinical AssessmentOTHER

HL treatment will be determined by review of available medical records as archived at MSKCC. Recorded variables will include: (1) RT - field, fractional and cumulative dose, and duration; (2) chemotherapy - regimen, planned interval, dose per cycle, and cumulative dosages. Patients will also be asked to complete the FACT-LYM questionnaire and the FACIT Fatigue questionnaire.

Stress cardiac MRIPROCEDURE

Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.

Stress echocardiogramPROCEDURE

Both imaging tests will be performed within a 30 day interval, with the two modalities interpreted by dedicated study investigators blinded to the results of the other modality.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center. * Age ≥ 18 years * Treatment for HL that included mediastinal RT at initial diagnosis or relapse. * ≥ 5 years from last HL treatment. Exclusion Criteria: * Primary HL diagnosis prior to 1980. * Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm. * Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function \[EF \< 55%\] during prior clinical care). * Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate \<30 ml/min/1.73m\^2). * Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).

Locations (1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Outcomes

Primary Outcomes

compare the prevalence of cardiac injury

detected by cardiac MRI to that detected by stress echocardiography among a broadly representative cohort of Hodgkin lymphoma survivors.

Time frame: 2 years

Data from ClinicalTrials.gov

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