The Effects of Rifampin on the Pharmacokinetics of Rosuvastatin

Inclusion Criteria: * Healthy Asian volunteers of Han-Chinese/Japanese/Korean descent whose parents and grandparents are Han-Chinese/ Japanese/ Korean. * Healthy Caucasian volunteers of White/Caucasian/European-born descent whose parents and grandparents are White/Caucasian/European. * Male or female, ages 18-65 years old, with no current medical conditions or active diagnoses as determined by the study doctor based on history, physical exam, and laboratory evaluations. * Subjects who take no other medications two weeks prior to the study and during the time course of the study including prescription medications, over-the-counter medications, dietary supplements, or drugs of abuse. * Subjects with the following genotype: SLCO1B1\*1a and ABCG2 421CC. * Subjects able to maintain adequate birth control during the study independent of hormonal contraceptive use. * Subjects able to abstain from grapefruit, grapefruit juice, oranges, orange juice, caffeinated beverages and/or alcoholic beverages from 7am the day before the study to completion of that study day. * Participants determined to have normal liver and kidney function as measured at baseline * BMI between 18.0 - 30 kg/m2 * Subjects capable of fasting from food and beverages at least 8 hours prior to medication dosing. * Be able to read, speak, and understand English. * Subjects capable of providing informed consent and completing the requirements of the study. Exclusion Criteria: * Subjects with active medical problems * Subjects on chronic prescription or OTC medication that cannot be stopped 2 weeks prior to and during the study. * Subjects incapable of multiple blood draws (HCT \< 30mg/dL) * Subjects with a history of rhabdomyolysis * Subjects with a history of drug-related myalgias * Subjects with a history or diagnosis of hemorrhagic tendencies or blood dyscrasias * Subjects with a history of GI bleed or peptic ulcer disease * Subjects who smoke tobacco or have ongoing alcohol or illegal drug use * Subjects who are pregnant, lactating, or trying to conceive during the study period * Subjects allergic to rosuvastatin or rifampin or any known component of the medications * Anyone who in the opinion of the study investigators is unable to do the study