Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
68
sevoflurane-based general anesthesia
total intravenous anesthesia
First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
Number of patients with postoperative cognitive dysfunction
Time frame: 7 days after surgery
Number of patients with postoperative cognitive dysfunction
Time frame: 3 months after surgery
Changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6 (a composite outcome measure)
Time frame: 3 days after surgery
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