IMSI in Couples With Previous Implantation Failures

Inclusion Criteria: * Patients with ICSI indication, who have previously underwent \>= 1 ICSI attempt in which at least 2 blastocysts were transferred, with no implantation. * Regular menstrual cycles every 25-35 days. * Body Mass Index less than 35 as calculated according to the following formula: body weight (kg) / height x height (m2) * Presence of both ovaries. * No pelvic and / or clinically significant uterine anomalies. * Normal cervical cytology. * Serum follicle stimulating hormone (FSH) within normal limits. Exclusion Criteria: * Clinically significant systemic disease. * Infection by the human immunodeficiency virus (HIV). * Infection by the by the hepatitis C virus * Positive test for surface antigens of hepatitis B. * Endometriosis stages III - IV (classification of the American Society for Reproductive Medicine). * Hydrosalpinx, unilateral or bilateral. * Abnormal gynecological bleeding, undiagnosed. * Allergy or hypersensitivity to human gonadotropin preparations or any other related to the study medication. -Simultaneous participation in another clinical trial. -