Will Adjusting the pH of Lidocaine Reduce the Pain During Injection of Local Anaesthetic?

Norwegian University of Science and Technology32 enrolled

Overview

This study will investigate the influence of adjusting the pH of lidocaine on pain during subcutaneous injection. Each participant will receive two injections on the abdomen with different pH. After each injection, the subject will be asked to evaluate the pain on a Visual analog scale (0-100 mm). It is anticipated that the pain decreases with increasing pH. The aim of the study is to find a simple method for pain reduction that can be used in clinical practice.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Needlestick Injuries

Interventions

Lidocaine injection with bicarbonatePROCEDURE

bicarbonate added to change pH

lidocaine injectionPROCEDURE

Lidocaine injection with pH unchanged

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: fyll inn * Age 18-65 years Exclusion Criteria: * Kidney, heart or liver disease * Eczema or psoriasis on injection site * Neuropathy * Regular use of painkillers * Hypersensitivity of Lidocaine * Pregnancy * Diabetes

Locations (1)

Department of Neuroscience, NTNU

Trondheim, Norway

Outcomes

Primary Outcomes

Pain

1. Visual Analog Scale 0-100 mm 2. Questionnaire

Time frame: 60 seconds

Data from ClinicalTrials.gov

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