Study to Evaluate the PK, Relative Bioavailability and Safety of TG-2349 With Single Oral Dose Under Fed Condition in Healthy Volunteers

Inclusion Criteria at Screening 1. East Asian or Caucasian subjects, male or female, and 18 to 40 years of age inclusive 2. Body mass index (BMI) in the range of 19.0 to 30.0 kg/m2 and body weight ≥ 50 kg inclusive 3. In general good physical and mental health status on the basis of a medical history review, medical evaluation including vital signs and physical examination, 12-lead ECG, and laboratory results at screening 4. For females, one of the following criteria must be fulfilled: (1)At least 1 year post menopausal, or (2)Surgically sterile, or (3)Willing to use a double-barrier method (intrauterine device \[IUD\] plus condom, spermicidal gel plus condom) of contraception from screening until 30 days after the last dose of study drug; 5.Males must be willing to use a reliable form of contraception (use of a condom or a partner fulfilling the above criteria) from screening until 30 days after the last dose of study drug 6.Willing to abstain from caffeine- or xanthine-containing beverages (including coffee and tea), alcohol, grapefruit juice, and Seville oranges during the stay-on-site period 7.Willing and able to provide written informed consent Exclusion Criteria at Screening 1. Positive serological test for IgM anti-HAV antibody, HbsAg, or anti-HCV antibody at screening 2. Positive ELISA test for HIV-1 or HIV-2 at screening 3. Any of the following abnormal laboratory values at screening: Hemoglobin (Hb) \<12.0g/dL for women and \<13.0g/dL for men, white blood cell count (WBC) \<3,000 cells/mm3, absolute neutrophil count \<1,500 cells/mm3, platelet count \<100,000 cells/mm3, serum creatinine ≥ 2 mg/dL, ALT or AST levels ≥ 2 xULN, total bilirubin ≥ 1.5 xULN, INR (International Normalized Ratios for prothrombin time) ≥1.5 xULN 4. Any abnormal laboratory values that are considered clinically significant by the Investigator at screening 5. QTcF greater than 450 msec for females and 430 msec for males at screening 6. History of renal, hepatic impairment, stomach or intestinal surgery or resection, malabsorption syndrome 7. History of seizures, epilepsy, cardiovascular, diabetes, or cancer (except basal cell carcinoma) 8. History or family history of prolonged QT interval or family history of sudden cardiac death at a young age (\< 30 years ) 9. History of drug allergy or hypersensitivity, especially to sulfa drugs 10. History or evidence of abuse of alcohol, barbiturate, amphetamine, recreational, or narcotic drug use within 6 months prior to first dose of study drug administration 11. Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of a psychiatric illness, or who have any history of suicide attempt or depression 12. Anemia or blood/plasma donation within 30 days prior to first dose of study drug administration 13. Pregnant or breast-feeding 14. Use of tobacco or nicotine-containing products within 30 days prior to first dose of study drug administration 15. Use of concomitant medication, including herbal remedies and dietary supplements (except for paracetamol/acetaminophen, ibuprofen, and hormonal contraceptives) within 14 days prior to first dose of study drug administration 16. Received any other investigational drug within 30 days prior to first dose of study drug administration Exclusion Criteria at the First Admission 1. Any of the following abnormal laboratory values at admission: Hb \<12.0g/dL for women and \<13.0g/dL for men, WBC \<3,000 cells/mm3, absolute neutrophil count \<1,500 cells/mm3, platelet count \<100,000 cells/mm3, serum creatinine ≥ 2 mg/dL, ALT or AST levels ≥ 2 xULN, total bilirubin ≥ 1.5 xULN, INR ≥ 1.5 xULN 2. Any abnormal laboratory values that are considered clinically significant by the Investigator at admission 3. Any clinically significant abnormality on 12-lead ECG or a QTcF greater than 450 msec for females and 430 msec for males at admission 4. Positive urine drug screen or breath alcohol test at admission 5. If female, positive serum pregnancy test at admission 6. Acute illness within 2 weeks prior to dosing, unless approved by the Sponsor's Medical Monitor