Towards Individualized Surgery in Non-focal Congenital Hyperinsulinism

University Medicine Greifswald14 enrolled

Overview

Observational study in patients with non-focal congenital hyperinsulinism showing that restrictive surgery may improve the metabolic situation

In non-focal congenital hyperinsulinism (CHI) the current doctrine warrants subtotal pancreatic resection in all children who do not respond to medication. However, the rate of diabetes after these extensive resections is very high. In this study investigators show that a less aggressive approach may suffice to wean many children from all medication or to get them manageable medically.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Non-focal Congenital Hyperinsulinism

Interventions

restrictive pancreatic resectionPROCEDURE

Restrictive, spleen-preserving resection of the pancreatic tail by laparoscopy

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with non-focal congenital hyperinsulinism Exclusion Criteria: * patients with focal congenital hyperinsulinism

Locations (1)

Pediatric Surgery

Greifswald, Germany

Outcomes

Primary Outcomes

necessity of medication after restrictive surgery in congenital hyperinsulinism

Time frame: up to 3 years

Data from ClinicalTrials.gov

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