MMP-9 Monitoring Particulate Cerebral Embolisation

Peking Union Medical College Hospital48 enrolled

Overview

1. In carotid endarterectomy(CEA) surgery, the dynamic changes of plasma MMP9 concentration cross CEA will be identified. 2. And the part of patients suffered particulate cerebral embolic injury, their MMP9 level will increase in the early stage after CEA.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cerebral Embolic Damage

Interventions

vein blood collectionPROCEDURE

5 ml peripheral vein blood samples were collected from each patient admitted to our study at the following time-points：Pre-operative（morning of surgery），just before declamping，30mins after declamping and post-operative（12h）.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: -All patients enrolled had at least ≥70% unilateral or bilateral stenosis of Internal -Carotid Artery， or those who had a \<70% stenosis but obvious cerebral ischema symptoms had been existed. Exclusion Criteria: * Exclusion criteria included poor temporal window * Refused to cooperate with us * Nonatheromatous such as takayasu arteritis and fibromuscular dysplasia.

Locations (1)

vascular surgery department of PUMCH

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

postoperative ischemic stroke

Time frame: 7 days after surgery

Secondary Outcomes

postoperative elevation of plasma MMP9

Time frame: perioperative phage

Data from ClinicalTrials.gov

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