Bed-rest, Muscle Mass and Insulin Sensitivity

Inclusion Criteria: * Male * Aged from 18-35 years * 18.5 \< BMI \< 30 kg/m2 Exclusion Criteria: * Smoking * Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months * Hypertension (according to WHO criteria) and/or cardiovascular disease * Any back/leg/knee/neck/postural complaints * Use of any prescribed medication * Type 2 diabetes mellitus * Any family history of thrombosis * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Myocardial infarction within the last 3 years * Use of anti-coagulants