Observational Study of Corneal Opacities in Adults

Oregon Health and Science University150 enrolled

Overview

A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imaging, will be performed for comparison.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Corneal Opacities (Scar and Stromal Dystrophy)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: • Adult (18 \& older) patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy) Exclusion Criteria: * Inability to give informed consent. * Inability to maintain stable fixation for OCT imaging. * Inability to commit to required visits to complete the study.

Locations (1)

Humberto Martinez

Portland, Oregon, United States

Outcomes

Primary Outcomes

Identification of suitable subjects

The primary goal of this observational study is to identify suitable subjects for the clinical trials of OCT-guided transepithelial PTK.

Time frame: 2 years

Secondary Outcomes

Validate OCT topography

A second goal is to validate OCT anterior topography by comparison with standard Placido-ring corneal topography and develop a mathematical model that relates epithelial thickness variation to corneal mean curvature.