Porphyromonas Gingivalis and Alzheimer's Disease

University Hospital Muenster90 enrolled

Overview

With this study the investigators would like to analyze the the role of periodontal disease and especially the role of Porphyromonas gingivalis in initiation and progression of Alzheimer's Disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Alzheimer's Disease Dementia Periodontitis

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 40-70 * caucasian origin * dementia (Alzheimer's or other dementia) * cognitive healthy (need for spinal anesthesia) Exclusion Criteria: * use of antibiotics within las 6 months * pregnancy * another illness explaining the symptoms in a better way * smoking (\>10 cigarettes) * patients who have a legal custodian

Locations (1)

Department of Periodontology

Münster, Germany

Outcomes

Primary Outcomes

Cmax Antibody Levels against Gingipains

laboratory analysis

Time frame: Baseline

Secondary Outcomes

Cmax Beta-Amyloid

laboratory analysis

Time frame: Baseline

Data from ClinicalTrials.gov

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