Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil

Helsinki University Central Hospital40 enrolled

Overview

The purpose of this study is to evaluate the effect of oral administration of probiotic Lactobacillus rhamnosus GG in middle ear and adenoid tonsil.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Upper Respiratory Infection Acute Otitis Media

Interventions

Lactobacillus rhamnosus GGDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 1 YearMax age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * recurrent otitis media * secretory otitis media * chronic rhinitis * recurrent sinusitis Exclusion Criteria: * significant illness

Outcomes

Primary Outcomes

Lactobacillus Rhamnosus GG in Middle Ear Effusion and Adenoid Tonsil

Presence of Lactobacillus rhamnosus GG in middle ear effusion of children having tympanostomy after oral administration of L. GG.

Time frame: After 3 weeks of oral consumption

Secondary Outcomes

Presence of Bacterial Pathogens in Middle Ear Effusion Samples

Association of Lactobacillus rhamnosus GG with occurrence of bacterial pathogens in the middle ear.

Time frame: After 3 weeks of oral consumption

Presence of Rhinovirus and Enterovirus in Middle Ear Effusion Samples

Association of Lactobacillus rhamnosus GG with occurrence of viral pathogens in the middle ear.

Time frame: After 3 weeks of oral consumption

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.