Chemotherapy Combined With Radiotherapy vs Chemotherapy Alone for Distant Metastatic Nasopharyngeal Carcinoma

Inclusion Criteria: * The patients with initial untreated metastatic nasopharyngeal carcinoma * Histologic diagnosis of nasopharyngeal carcinoma * T1-4N0-3M1,IVC(according to the 7th AJCC edition) * Aged between 18 and 65 years * KPS≥70 * The therapeutic effect evaluation is CR or PR accomplished three course of cisplatin and 5-Fu * Voluntary to participate and sign informed consent document Exclusion Criteria: * The patients suffered from serious neurologic disease * Clinically significant cardiac, heart function less than or equal to 3 level * Clinically significant respiratory disease,lung function less than or equal to 3 level * Blood routine examination: WBC\<3×109/L, Hemoglobin\<90g/L, platelet count\<75×109/L * Abnormal liver function: total bilirubin or ALT or AST\>2×ULN * Abnormal renal function:serum creatinine\>1.5×ULN * Pregnant or lactating women * The therapeutic effect evaluation is SD or PD accomplished three course of cisplatin and 5-Fu