The study is designed to answer the following questions: 1\) What is the effect of testosteron replacement treatment on the endothelial dysfunction. 2/ What is the effect of testosteron replacement on the bone mineral metabolism.
this is an interventional study which is examine the effect of testosteron replacement treatment on the endothelial dysfunction and bone mineral metabolism in hypogonadotropic hypogonadal patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
49
Testosterone 250 mg injection per 3-4 weeks for 6 months
Gulhane School of Medicine
Ankara, Turkey (Türkiye)
the effect of testosteron replacement treatment on the Fibroblast Growth Factor-23.
Plasma FGF-23 levels were determined by ELISA, (Human Intact FGF-23 ELISA Kit, Inc., San Clement, CA, USA).
Time frame: 6 months
the effect of testosteron replacement treatment on the asymmetric dimethylarginine.
Plasma ADMA levels were determined by ELISA (Immunodiagnostic, Bernheim, Germany)
Time frame: 6 months
the effect of testosteron replacement treatment on the vitamin D levels.
Plasma 25-OH vitamin D3 levels were measured by Immuchrom kits (Hessen, Germany) using isocratic HPLC method with UV detector in Prominence HPLC system.
Time frame: 6 months.
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