Malnutrition is a prominent clinical feature of patients affected by systemic immunoglobulin light-chain amyloidosis (AL), with a prevalence ranging between 25-50%. Although the prognosis predominantly depend on the presence and severity of cardiac involvement, it was shown that malnutrition is an independent predictor of survival and quality of life. However, the assessment of nutritional status by common indices based on anthropometry is not always feasible and accurate due to reduced performance status and/or the presence of fluid imbalances (for example edema and ascites). Several recent studies have demonstrated the prognostic value of the phase angle. Moreover, the value is supported by its applicability to patients who are bedridden or present alterations in the state of hydration.
Study Type
OBSERVATIONAL
Enrollment
127
Standard dietary advice are provided to all patients at baseline and during the follow-up to all requiring or asking for
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Mortality
All-cause mortality at 12 months since baseline assessment
Time frame: 12 months
Quality of life
Association between phase angle and quality of life at baseline and 6 months. Association between changes in phase angle and in quality of life at 6 months.
Time frame: 6 months
Mortality
Association between phase angle and its changes at 6 months and mortality at 12 months.
Time frame: 12 months
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