Calypso-based Deep Inspiration Breath Hold (DIBH) Radiation Treatments of Lung Cancer

Inclusion Criteria: * Patients must have histologic proof of malignancy suitable for thoracic radiation therapy * Patients planning to undergo radiation therapy for primary or recurrent malignancy of the lung or metastatic malignancy to the lung. * Age ≥ 18 years old * KPS ≥ 60% * Ability to hold their breath for \>20 seconds for 5 times * Patients who are able to tolerate flexible bronchoscopy * Patients with life expectancy of at least 12 months * Patients able to have bronchoscopic placement of Calypso as confirmed on a recent (within the past 8 weeks) CT scan. * Patients who are able to comply with the protocol follow-up schedule. Exclusion Criteria: * Patients unable to comply with instructions for DIBH * Patients with implants in the chest region that contain metal or conductive materials (e.g., metal implants, rods, or plates) which Calypso Medical considers will interfere with the Calypso System's electromagnetic localization. * Patients with active implanted devices, such as pacemakers, defibrillators, and drug infusion pumps since the effects of the Calypso System operation on these devices are unknown. * Patients with clinically significant active infections. * Patients with bronchiectasis in the region of the intended implantation sites. * Patients with a history of hypersensitivity to nickel. * Patients whose lung tumors are being monitored with MR imaging (MR imaging of the anchored transponders is safe but yields an image artifact around the anchored transponders). * Posterior lesions that would be \>19cm distance from Calypso detector plate. Patients may be treated in the prone position in order to meet the required minimum distance. * Patients with any other medical condition or laboratory value that would, at the discretion of the investigator, preclude the patient from participation in this clinical study. * Patients who are deemed unable to safely undergo or tolerate flexible bronchoscopy * Patients who are unable to tolerate anesthesia or sedation * Patients enrolled in any other clinical studies the investigator believes to be in conflict with this investigation. * Female patients who are pregnant or nursing