Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICU

Ligue Pulmonaire Genevoise60 enrolled

Overview

There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not known in this population. This prospective cohort describes the clinical profile, predictors of readmission (followed over a year), and the prevalence of sleep-related breathing disorders (polysomnography in a stable clinical condition 3 months after ICU discharge) in patients treated for an episode of acute hypercapnic respiratory failure in the ICU.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Hypercapnic Respiratory Failure

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years Informed consent surviving an episode of acute hypercapnic respiratory failure Exclusion Criteria: * iatrogenic hypercpania pregnant woman

Locations (1)

Hôpitaux Universitaires de Genpve

Geneva, Switzerland

Outcomes

Primary Outcomes

Sleep apnea syndrome

Apnea-Hypopnea Index defined by polysomnography

Time frame: at 2 month after ICU discharge

Sleep Hypoventilation

defined by AASM 2012 criteria with transcutaneous PtCO2 monitoring

Time frame: at 2 month after ICU discharge

Secondary Outcomes

Lung physiology ( obstructive or restrictive lung disease)

FEV1, VC, TLC, DLCO

Time frame: at week 2 after ICU discharge

Inspiratory Muscle Strength

Sniff nasal maximal inspiratory pressure, Mouth inspiratory pressure

Time frame: at week 2 after ICU discharge

Cardiac function

Systolic and diastolic cardiac function, pulmonary hypertension

Time frame: at week 2 after ICU discharge

Hospital and ICU readmission rate

Time frame: 1 year follow-up after ICu discharge