Icariin to Prevent Corticosteroid-related Memory Changes

Inclusion Criteria: * Healthy men and women * Ages 18 - 50 years * BMI between 18.5 and 30 * Ability to read and speak English * Education of 12 or more years or equivalent (at least GED received) Exclusion Criteria: * Medication changes in the past 30 days * History of psychotropic medication therapy in the past 30 days * Current or past 30 days opioid therapy * Current or past 30 days erectile dysfunction therapy * Significant medical conditions * Hypertensive blood pressure, defined as either systolic pressure \> 140 or diastolic pressure \> 90 * Baseline heart rate \> 100 bpm or \< 50 bpm * History of major psychiatric illness * History of drug/alcohol abuse or current tobacco use * Vulnerable populations including pregnant or nursing women, the incarcerated, or individuals with severe cognitive disorders * History of allergic reaction or contraindication to icariin * Baseline QIDS score \> 7, current suicidal ideation, or history of suicide attempt * Education history that includes Special Education or history of mental disability * Clinically significant abnormalities on baseline labs and ECG results * Current participation in any other pharmacotherapy studies