The endocannabinoid (eCB) system, a neurochemical signalling system consisting of CB-receptors and their endogenous ligands, has been found to be involved in food intake of sweet and palatable foods. Activation of the eCB system increases food intake and vice versa. The mechanism behind this effect is still unknown and the current study aims at clarifying why sweet food intake increases. It is hypothesized that sweet taste intensity increases and that sweet taste is experienced as more pleasant.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
10
Wageningen University
Wageningen, Gelderland, Netherlands
Relation between sweet taste intensity and liking
The main study parameter is the relation between sucrose intensity scaling (psychophysics) and liking (psychohedonics) of drinks with the different sucrose concentrations. These scores will be assessed after six participants and at end of the study.
Time frame: 15 minutes after intervention
Ranking order of pleasantness of different drinks with different levels of sucrose.
Ranking order will be assessed after 6 participants and at end of the study
Time frame: 25 minutes after intervention
Preferences for different kinds of foods
Preference for foods high in one of three macronutrients (carbohydrate, protein, fat) or low in energy
Time frame: 45 minutes after intervention (15 minutes after top-up dose)
Ad libitum intake
Ad libitum intake of a chocolate-based drink
Time frame: 35 minutes after intervention (5 minutes after top-up dose)
Change of plasma levels of (endo-)cannabinoids and satiety hormones
Time frame: One hour after intervention
Polymorphisms
The genetic determination of the enzymes responsible for the metabolism of THC and CBD.
Time frame: At test session, i.e., 2 weeks before first intervention
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