Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children

Queen Sirikit National Institute of Child Health40 enrolled

Overview

The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate

Intervention: At randomization eligible patients were allocated to receive 2.5ml of isotonic magnesium sulphate (150 mg,245 mmol/L) on three occasional at 20 minutes interval or standard treatment 50 mg/kg intravenous magnesium sulphate. The asthma severity score was record at 0,20,40,60,120,180,240 minutes post randomization. Adverse event were assessed at each assessment point. Patients were followed up until discharge from hospital to collect secondary outcome data.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acute Severe Asthma

Interventions

isotonic magnesium sulphateDRUG

2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) NB on three occasional at 20 minutes interval

50% magnesium sulphateDRUG

magnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose

Eligibility

Sex: ALLMin age: 2 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children age 2-15 years presenting with severe asthma or persistent wheeze without responding to conventional therapy Exclusion Criteria: * chronic lung disease * history of adverse reaction form magnesium sulphate * life threatening condition

Locations (1)

Queen Sirikit National Institute of Child Health

Bangkok, Thailand

Outcomes

Primary Outcomes

Asthma severity score

Time frame: 60 minute

Secondary Outcomes

Length of stay in the hospital

Time frame: within 2 weeks

Data from ClinicalTrials.gov

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