Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role. Dexamethasone is a very potent anti-inflammatory drug. The hypothesis of this study is that dexamethasone, given pre operatively, would help reduce the incidence of post thoracotomy pain syndrome 3 months after surgery, by reducing the inflammatory response, in patients undergoing elective thoracic surgery that includes thoracic epidural analgesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
60
10 mg (2.5 ml)
2.5 mL normal saline
Maisonneuve-Rosemont Hospital
Montreal, Quebec, Canada
RECRUITINGcytokine elevation
Time frame: 24 h after surgery
incidence of post thoracotomy pain syndrome
Time frame: 3 months after surgery
incidence of post thoracotomy pain syndrome
Time frame: 6 months after surgery
incisional and shoulder pain
Time frame: acute post operative period
Brief pain inventory questionnaire
Time frame: three months after surgery
Brief pain inventory questionnaire
Time frame: 6 months after surgery
Leeds Assessment of Neuropathic Signs and Symptoms questionnaire
Time frame: three and six months after surgery
cytokine elevation
Time frame: 1h after surgery
cytokine elevation
Time frame: 48 h after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.