Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography

Isfahan University of Medical Sciences

Overview

As the effect of statin use before the angiography to prevent contrast induced nephropathy (CIN) is not well-known, the aim of the current study is to assess the effect of atorvastatin on prevention of CIN in patients undergoing coronary angiography.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Conditions

Contrast Induced Nephropathy

Interventions

AtorvastatinDRUG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * having chronic stable angina who were referred for coronary angiography * non-pregnant female subjects * no history of diabetes mellitus * no history of renal failure * no history of single kidney * no history of cardiogenic shock * no history of unstable angina * no history of myocardial infarction * no history of hypersensitivity to statins * no history of previous intravascular contrast injection during one month before admission Exclusion Criteria: * glomerular filtration rate (GFR) \<60 * cardiogenic shock

Locations (1)

Unnamed facility

Isfahan, Isfahan, Iran

RECRUITING

Outcomes

Primary Outcomes

Contrast induced nephropathy (CIN) incidence

CIN is determined as an increase in post-procedural serum creatinine of \> 0.5 mg/dl or \> 25% from baseline in the absence of any other causes

Time frame: 48 hours after the procedure

Secondary Outcomes

serum creatinine (Cr) level

Time frame: 48 hours after the procedure

Data from ClinicalTrials.gov

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