A Study Comparing the Efficacy and Safety of Orally Administered Ibuprofen and Placebo in Delayed Onset Muscle Soreness

Inclusion Criteria: * are male or female, 18-55 years of age * are a sexually active female of childbearing potential willing to use a medically acceptable form of birth control throughout the study and for 30 days following the end of study participation * have a history of experiencing muscle soreness after moderately strenuous exercise * are in good general health, with a BMI less than or equal to 30, and able to perform the exercise regimen * are able to read, comprehend, and sign the informed consent form * develop muscle pain/soreness within 24-48 hours of the end of the exercise regimen and have a baseline muscle pain/soreness with movement of greater than or equal to 5 on the NRS (numerical rating scale) and at least "moderate" on the categorical scale Exclusion Criteria: * regularly works out or exercises the upper extremities with weights or gym equipment during the past 6 months * works in an occupation that requires regular heavy lifting or involvement of the upper extremities (eg: mover, construction workers) * allergy or intolerance to any non-steroidal anti-inflammatory drug (NSAID), aspirin or acetaminophen * the presence of any medical condition (eg: history of bleeding ulcers or current peptic ulcer disease) that would preclude the subject from safely participating in the study' * any form of arthritis that requires prescription or over-the-counter (OTC)treatment pregnant or lactating female * current habituation or history of chronic use of analgesic or drugs or severe chronic pain problems that do not respond to OTC medication and/or requires a prescription analgesic * currently on chronic NSAID therapy for any reason * current or recent history of drug or alcohol abuse * has taken an analgesic medication within 5 half lives of performing the exercise regimen during the run-in period or completing the baseline assessment * has donated blood within the past 30 days * is unable to swallow whole or large tablets or capsules * is unable/unwilling to remain at the study center for the 6 hour inpatient observation period. * participation in an investigational study within the past 30 days of screening * prior participation in this trial * site employee or close relative of a site employee directly involved in the conduct or the study or is an employee or close relative of the study doctor.