Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine

Inclusion Criteria: * Males and non-pregnant females, ages 18 to 50 years inclusive. * Diagnosis of genital HSV-2 infection for \> 1 year supported by ONE of the following documented in the medical history or performed at screening: * Western blot for HSV-2 * Type-specific polymerase chain reaction (PCR) or viral culture * Compatible clinical history AND * Positive HerpeSelect® 2 Enzyme-linked Immunosorbent Assay (ELISA) Immunoglobulin G (IgG) with an index value \>3.5, or * Positive LIAISON® HSV-2 Type-Specific IgG * A history of at least 3 and no more than 9 reported clinical occurrences in the prior 12 months, or, if currently on suppressive therapy, history of at least 3 and no more than 9 reported clinical occurrences in the 12 months prior to initiation of suppressive therapy. * Collection of at least 45 of 56 anogenital swabs during the baseline period. * Willing and able to provide written informed consent. * Willing to perform and comply with all study procedures including attending clinic visits as scheduled. * Men and women of childbearing potential, must be willing to practice a highly effective method of contraception that may include, but is not limited to, abstinence, monogamous relationship with vasectomized partner, vasectomy, licensed hormonal methods, intrauterine device (IUD), or barrier method (e.g., condom, diaphragm) for 28 days before and 90 days after receiving Study Drug. Exclusion Criteria: * On suppressive antiviral medication within 7 days of beginning baseline anogenital swab collection period. * History of genital Herpes Simplex Virus type-1 (HSV-1) infection. * History of any form of ocular Herpes Simplex Virus (HSV) infection, HSV-related erythema multiforme, or herpes meningitis or encephalitis. * Immunocompromised individuals, including those receiving immunosuppressive doses of corticosteroids (more than 20 mg of prednisone given daily or on alternative days for 2 weeks or more within 6 months prior to the first dose of Study Drug, any dose of corticosteroids within 30 days of the first dose of Study Drug, or high dose inhaled corticosteroids \[\> 960 μg/day of beclomethasone dipropionate or equivalent\]) or other immunosuppressive agents. * Presence or history of autoimmune disease, regardless of current treatment. * Positive serologic test for Human Immunodeficiency Virus (HIV-1) or hepatitis C infection; positive hepatitis B surface antigen (HBsAg). * Clinically significant laboratory abnormality or a value ≥ Grade 2. * Prior immunization with a vaccine containing HSV-2 antigens. * History of hypersensitivity to any component of the vaccine. * Receipt of any investigational drug within 30 days prior to the first dose of Study Drug. * Receipt of blood products within 90 days prior to the first dose of Study Drug. * Receipt of a live vaccine within 28 days prior to or a subunit vaccine within 14 days prior to the first dose of Study Drug or planned vaccination within 30 days following the last dose of Study Drug. * Pregnant or nursing women. * History of drug or alcohol abuse that, in the opinion of the Investigator, would interfere with the patient's ability to comply with the requirements of the study. * Other active, uncontrolled co-morbidities that, in the opinion of the Investigator, would make the subject unsuitable for the study or unable to comply with the study requirements. NOTE: Subjects who are taking a medication to control an underlying co-morbidity may be enrolled if there have been no changes to their medication within 60 days prior to the first dose of Study Drug.