Chemotherapy Options for the First Line Chemotherapy in Elderly Patient With Advanced Gastric Cancer

Inclusion Criteria: * .Metastatic or recurrent, histologically confirmed adenocarcinoma of stomach - Previously untreated patients, including patients with previous adjuvant chemotherapy completed more than 6 months * 70 yrs or older * Eastern Cooperative Oncology Group 0-2 * Measurable or evaluable disease * Adequate major organ functions * Hb ≥ 9.0 g/dL * White blood cell count ≥ 3000/μL * Absolute Neutrophil Count (ANC) ≥ 1500/μL \[\*ANC = neutrophil segs ＋ neutrophil bands\] * Platelet ≥ 100 × 103/ μL * Total bilirubin ≤ 1.5 ×UNL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ≤ 3.0x UNL(in case of liver metastasis, AST/ALT ≤ 5.0 x UNL) * Serum creatinine ≤ 1.5 × UNL (in case of serum creatinine \> 1.5 mg/dL , Ccr should be \>= 50 mL/min, Ccr is calculated by Cockcroft-Gault or 24hr urine collection) * Life expectancy \> 3month * Written informed consent Exclusion Criteria: * Metastatic or recurrent stomach cancer other than adenocarcinoma * HER-2 positive * Clinically significant, uncontrolled gastric outlet obstruction, bleeding, or perforation * Radiation therapy within the previous 2wks * Major surgery or trauma within the previous 4wks * Other malignancies within the last 5 years (other than curatively treated basal cell carcinoma of the skin and/or in situ carcinoma of the cervix) * Uncontrolled brain metastasis * Presence of other serious disease (cardiovascular, hepatic, infection etc.) * Patients who participated in other clinical trials within the previous 30days * Men of childbearing potential not willing to use effective means of contraception