Radioactive iodine (RAI) administration is an effective and completely established treatment modality in hyperthyroidism including Graves' disease. Despite the long experience with radioiodine for hyperthyroidism, controversy remains regarding the optimal dose of iodine that is required to achieve long-term euthyroidism. The fixed activity administration method does not optimize the therapy, giving often too high or too low radiation to the gland, but the optimal dose per gram of thyroid mass in calculated activity administration method is also under much debates. This prospective study has been designed in order to compare the effect of different calculated doses of radioiodine on Graves' disease treatment outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
450
We wil administer 100 micro currie of iodine per thyroid gram
We will administer 150 micro currie of iodine per thyroid gram
We will administer 200 micro currie of iodine per thyroid gram
Nuclear Medicine Research Center, Ghaem Hospital
Mashhad, Khorasan-Razavi, Iran
RECRUITINGchange of thyroid related hormones blood level from baseline at 1,3,6 and 12 month
thyroid-stimulating hormone (TSH), T4, T3
Time frame: 1,3,6,12 month
Rate of hypothyroidism status at 1, 3,6 and 12 month post RAI therapy
Hypothyroidism index
Time frame: 1,3,6,12 month
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