This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol.
This prospective clinical trial evaluates the effect of a two dose GnRH agonist administered in the luteal phase on the outcome of ART cycles stimulated with the long GnRH agonist and GnRH antagonist protocol. Decision between each of these two protocols was subjective and depended on the clinical context.In addition to routine luteal phase support with progesterone and estradiol valerate,women received two dose of GnRH agonist on the fifth and tenth day after ET.Live birth rate was the primary outcome measure.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
100
in experimentals groups,on fifth and tenth day after embryo transfer 0,5mg leuprolide acetate is given subcutaneously as luteal phase support
crinone gel is applied till fetal heart beat is detected
estrofem is given twice a day
Zekai Tahir Burak Hospital
Ankara, Cankaya, Turkey (Türkiye)
Live Birth Rate
Time frame: 42 weeks
Ongoing pregnancy
Time frame: more than 20 weeks
miscarriage
Time frame: up to 20 weeks
OHSS
Time frame: up to 10 weeks
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