Evaluation of Phage Therapy for the Treatment of Escherichia Coli and Pseudomonas Aeruginosa Wound Infections in Burned Patients

Inclusion Criteria: * Man or woman * Adult Informed consent obtained from patient or next of kin * In-hospital patient treated for burn wounds in a burn unit * Burn wound (grafted or not) or graft harvesting area, presenting local signs of infection defined by SFETB criteria: * A local or loco-regional inflammatory reaction; * And/or an adverse and unexpected local evolution; * And/or regarding burn wounds: presence of pus, fast spontaneous debridement and separation, occurrence of blackish spots (necrosis or haemorrhage), unexplained conversion from a superficial lesion to a deep one (\> 48th hour); * And/or regarding graft donor sites: presence of pus, unexplained delay in epidermisation, bedsore; * And/or regarding graft recipient sites: presence of pus, lysis of grafts, necrosis of fat located under the graft. * Burn wounds with a microbiologically documented infection, as defined by positive surface swab, due to Escherichia coli or Pseudomonas aeruginosa whatever their resistance profile * Treated by povidone-iodine Exclusion Criteria: * Pregnant or breastfeeding woman * Intercurrent condition requiring a treatment which may interfere with analysis results: such as high dose of chronic corticotherapy, immunosuppressive medication, oncologic chemotherapy * Patient included in an interventional research protocol with therapeutic intervention still ongoing upon inclusion time or having participated into anti-infective drug trials during the previous month. * Patient considered as part of a vulnerable population * Patient for whom treatment limitation or withdrawal during study period is considered * Allergy to Silver Sulfadiazine