The Opioid-sparing Effect and Reduced PONV Using Propacetamol in PCA Among Patients With High Risk of PONV

Yonsei University108 enrolled

Overview

While Patient-controlled analgesia (PCA) has the advantage of effectively reducing the degree of postoperative pain, it can also affect the patient's outcome by several adverse effects such as postoperative nausea and vomiting (PONV). Especially for high risk group of patients for PONV, the ideal regimen for sufficient analgesia with minimal adverse effect needs to be sought. Propacetamol is known for its effective, rapid analgesia, opioid-sparing effect, and is used widely for post operative pain management. This study aims to see the opioid-sparing effect and the degree of PONV when propacetamol is added to PCA for high risk PONV patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

108

Conditions

PONV Propacetamol

Interventions

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients scheduled for either 1-2 level spine fusion or laminectomy 2. ASA (American Society of Anesthesiology) physical status 1 or 2 3. Non-smoking female patients, between the age 20 and 65 Exclusion Criteria: 1. Administration of any anti-emetic agents within 24 hours prior to surgery 2. Administration of any opioid agents within 7 days prior to surgery 3. Regular administration of any steroid agents 4. Drug or alcohol-abuser 5. Patients with bowel movement disorder, liver or renal impairment, insulin-dependent diabetes. Patients who are pregnant, illiterate, or foreign. 6. Patients administered to Intensive Care Unit after surgery

Outcomes

Primary Outcomes

Incidence of PONV

Incidence of postoperative nausea, vomiting - Number of events

Time frame: from immediate postop to 24 hours after the surgery