The main objective of this study is to evaluate decision-making using the Iowa Gambling Task (IGT) among patients with euthymic bipolar disorder according to their personal history of suicide attempt ("suicidal" vs. "not suicidal ").
The secondary objectives of this study are: A. Evaluate other aspects of cognitive functioning (using the Tower of London, the Probabilistic Reversal-learning task, the Rey Complex Figure, the Reading the Mind in the Eyes test) in euthymic patients with bipolar disorder, depending on the presence or absence of a history of suicide attempt; B. Explore performance on neuropsychological tests depending on the type of therapy administered (lithium salts or valproate monotherapy or in combination with other mood stabilizers); C. Explore a possible relationship between circulating levels of lithium or sodium divalproex results and different neuropsychological tests; D. Establishment of a biobank for this population with leftover blood samples following serum lithium or divalproex testing.
Study Type
OBSERVATIONAL
All patients are interviewed at the BEC. Questionnaires and scores are administered. See endpoints.
Neuropsychological tests are administered (requires computer use). See endpoints.
Venous blood is drawn and tested for serum concentration of lithium or sodium divalproate.
Columbia-Suicide Severity Rating Scale (C-SSRS)
Time frame: Baseline (day 0)
The Iowa Gambling Task
Time frame: Baseline (day 0)
The Tower of London Test
Time frame: Baseline (day 0)
The Probabilistic Reversal Learning Task
Time frame: Baseline (day 0)
The Rey Osterreith Complex Figure Task
Time frame: Baseline (day 0)
The Baron-Cohen Test
Time frame: Baseline (day 0)
Serum concentration for divalproate (mg/l)
Time frame: Baseline (day 0)
Serum concentration for lithium (mEq/l)
Time frame: Baseline (day 0)
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