TD-6450 MAD Study in HCV Infected Subjects

Inclusion Criteria: * Subject is HCV antibody positive * Subject is treatment naïve, with no history of exposure (single or multiple dose) to interferon, ribavirin or direct acting antivirals. * Subject has had a liver biopsy within 3 years or Fibroscan evaluation within 6 months prior to Screening that clearly excludes cirrhosis. If not available prior to Screening, the absence of cirrhosis must be confirmed prior to subject enrollment using either Fibroscan or Fibrosure®. * Subject is negative for hepatitis A (HAV), hepatitis B (HBV), and human immunodeficiency virus (HIV). Exclusion Criteria: * Subject has prior histological evidence of cirrhosis or current clinical evidence of cirrhosis in the opinion of the investigator. * Subject has a history or evidence of non-hepatitis C chronic liver disease. * Subject has an estimated creatinine clearance of \<80 ml/min if 18-60 years of age, inclusive; or \<70 ml/min if \>60 years of age, calculated using the Cockcroft-Gault equation.