Mesenchymal Stem Cell Injection in Amyotrophic Lateral Sclerosis

Inclusion Criteria: 1. sporadic ALS according to escorial criteria 2. onset of disease with spinal cord involvement, Less than 3 years of disease onset with disease progression at 6 past months 3. mild to moderate spinal and bulbar disability,at least having score3 in swallowing, 2 in chewing and waking in ALS-FRS and FVC(functional vital capacity) equal or more than 50% of prediction amount 4. normal polysomnography 5. Signed consent form Exclusion Criteria: 1. pregnancy or lactation, 2. vascular disease,diabetes, systemic disease as cancer, autoimmune , liver or hematologic disease 3. Hospitalization due to serious illness in the last two months 4. survival time less than two years 5. Hypersensitivity to any component used in the cell culture