To evaluate the effect and safety of mivacurium chloride in pediatric patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
1,152
intravenously injected during induction with the dose according to allocated group, and intravenously injected with the dose of 0.1 mg/kg when T1 recovers to 25% during period of maintenance.
Before induction: after moving into operating room, oral administration with dose of 0.5 mg/kg or mixed with ketamine (midazolam 10 mg+ ketamine 100 mg) with dose of 0.1 ml/kg by intramuscular route for uncooperative children Induction: for children who didn't receive mixture of midazolam and ketamine before induction, it will be given with the dose of 0.05 ml/kg
mixed with ketamine (midazolam 10 mg+ ketamine 100 mg) with dose of 0.1 ml/kg by intramuscular route for uncooperative children Induction: for children who didn't receive mixture of midazolam and ketamine before induction, it will be given with the dose of 0.05 ml/kg
intubation score
Krieg Tracheal Intubation Score * Score : 1 2 3 4 * Laryngoscopy : Easy Fair Difficult Impossible * Vocal cords: Open Moving Closing Closed * Coughing: None Diaphragm Mild Severe * A total score of 3-4 = excellent, 5-7 = good, 8-10 = poor, 11-12 = bad.
Time frame: 1 minute within intubation
muscle relaxation effect
* Recording T1 and TOFR(Train of four ratio) before/after the induction of anesthesia -Onset time of Mivacurium:time from end of injection until occurrence of maxi- mum block * Duration of clinical relaxation:time to recovery of Tl(the first response in the TOF) to 25% * Recovery index:Time interval during with T1 recovered from 25%
Time frame: from baseline to no more than 120 minutes after intubation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Induction: 2 to 3 mg/kg Maintenance: 50 to 100 mcg/kg/min
Induction: 2 mcg/kg Maintenance: 0.1 to 0.3 mcg/kg/min