This study investigates the effects of a dietary supplement - a cocktail of vitamins and minerals - on the incidence of common cold in a cohort of middle management employees.The primary outcome is defined as the number of duty days lost due to common cold/flu. Further, immune parameters and markers of redox biology/oxidative stress will be determined. The wellbeing in the cohort will be evaluated via questionnaires.
randomized, double-blinded, placebo controlled trial 82 Subjects, men and women, 25 - 50 yrs, non-smokers, employees of middle management, 24 weeks of supplementation/placebo, 4 wk wash-out of all supplements and dietetic products, undersupply of fruit, vegetables (\< 4 portions/day) and whole grain food (\< 5x/wk)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
82
given for 24 weeks, after 4 week wash out of all supplements and dietetic products
given for 24 weeks, after 4 weeks wash out of all supplements and dietetic products
Institute of Pathophysiology and Immunology
Graz, Styria, Austria
Incidence of common cold
vitamins and minerals might influence the incidence of common cold in middle aged management employees
Time frame: 24 weeks
change in immune markers
cytokine levels and expression of cytokine receptors in leucocytes may change over time due to micronutrient intervention
Time frame: 24 weeks
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